³ He is despised and rejected by men, A Man of sorrows and acquainted with grief. And we hid, as it were, our faces from Him; He was despised, and we did not esteem Him.

 ⁴ Surely He has borne our griefs And carried our sorrows; Yet we esteemed Him stricken, Smitten by God, and afflicted.

 ⁵ But He was wounded for our transgressions, He was bruised for our iniquities; The  chastisement for our peace was upon Him, And by His stripes we are healed.

 ⁶ All we like sheep have gone astray; We have turned, every one, to his own way; And the LORD has laid on Him the iniquity of us all. (Isa 53:3-6)

They shall ask the way to Zion, With their faces toward it, `Come and let us join ourselves to the LORD,  a perpetual covenant not to be forgotten.’ ⁶ “My people have become lost sheep. Their shepherds have led them astray; They have turned them away on the mountains. They have gone from mountain to hill; They have forgotten their resting place. (Jer 50:5-6)

These twelve Jesus sent out and commanded them, saying: “Do not go into the way of the Gentiles, and do not enter a city of the Samaritans. ⁶ “But go rather to the lost sheep of the house of Israel. (Mat 10:5-6)

And behold, a Canaanite woman (not of the 12 tribes) came out from that region, and began to cry out, saying, “Have mercy on me, O Lord, Son of David; my daughter is cruelly demon-possessed.”

 ²³ But He did NOT answer HER a word. And His disciples came to and kept asking Him, saying, “Send her away, for she is shouting out after us.”

 ²⁴ But He answered and said (TO HIS DISCIPLES) , “I was not sent but for the lost sheep of the house of Israel.” (Mat 15:22-24)

So, according to Isaiah, Jeremiah, and Yeshua, the lost sheep of the House of Israel are comprised of not only those of the nations, and not only Ephraim, but Judah as well. All who have not placed themselves under the Shepherd Yeshua are ‘lost sheep’. For Yeshua came to seek and to save that which was lost  – which is everyone that has not accepted Him for Who He Is. .